Diet Modulates Endogenous Thrombin Generation, A Biological Estimate of Thrombosis Risk, Independently of the Metabolic Status
| Autor: | C. Sanchez, Marjorie Poggi, Stéphane Tanguy, Pierre-Emmanuel Morange, Michel Grino, Jean-Charles Martin, Anne Dutour, Marie-Christine Alessi, Catherine Defoort |
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| Přispěvatelé: | Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition humaine et lipides : Biodisponibilité, métabolisme et régulation, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Recherche Agronomique (INRA)-Université de Provence - Aix-Marseille 1-IFR125-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée (TIMC-IMAG-PRETA), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Fibrinolyse et Pathologie Vasculaire, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Timone [CHU - APHM] (TIMONE), Stago, Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF) |
| Rok vydání: | 2012 |
| Předmět: |
Time Factors
030204 cardiovascular system & hematology MESH: Thrombin MESH: Phenols 0302 clinical medicine prevention MESH: Fatty Acids Omega-3 Risk Factors MESH: Risk Factors Hyperinsulinemia MESH: Obesity MESH: Animals Diet Fat-Restricted 2. Zero hunger chemistry.chemical_classification 0303 health sciences MESH: Middle Aged Middle Aged MESH: Nutritional Status thrombin MESH: Insulin Resistance MESH: Models Animal peripheral vascular disease Docosahexaenoic acid MESH: Blood Coagulation Models Animal Cardiology and Cardiovascular Medicine medicine.drug Polyunsaturated fatty acid medicine.medical_specialty MESH: Rats Nutritional Status Biology Diet High-Fat 03 medical and health sciences Thrombin Insulin resistance Phenols [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system MESH: Diet Fat-Restricted Internal medicine Fatty Acids Omega-3 medicine Animals Humans Weaning Obesity MESH: Thrombosis Rats Wistar coagulation Blood Coagulation 030304 developmental biology MESH: Humans MESH: Time Factors Fatty acid Thrombosis MESH: Rats Wistar medicine.disease Rats MESH: Diet High-Fat Endocrinology chemistry Insulin Resistance diet |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology Arteriosclerosis, Thrombosis, and Vascular Biology, 2012, 32 (10), pp.2394-404. ⟨10.1161/ATVBAHA.112.250332⟩ Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2012, 32 (10), pp.2394-404. ⟨10.1161/ATVBAHA.112.250332⟩ |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/atvbaha.112.250332 |
| Popis: | Objective— High endogenous thrombin potential (ETP) is associated with venous and arterial thrombosis. Better knowledge of environmental influences on ETP may help to prevent thrombosis. Methods and Results— Weaning rats exhibited high ETP values that decreased in low-fat diet and remained elevated on high-fat diet. In adult rats, high-fat diet–induced ETP increase was independent of coagulation factors, obesity, and insulin resistance and negatively associated with polyunsaturated fatty acid levels. Switching from high-fat diet to low-fat diet reversed the procoagulant phenotype with a slower kinetic than the normalization of hyperinsulinemia. In humans, ETP was independent of body weight whereas it was negatively associated with nutritional markers such as the percentage of energy provided by proteins, the protein:fat ratio, circulating phenolic compounds, and omega-3 polyunsaturated fatty acid. A recommended 3-month healthy diet with reduced energy density, including lipids, decreased ETP (−21%; P Conclusion— Diet plays a pivotal role in regulating ETP, independently of obesity and insulin resistance. Global nutritional recommendations could be useful in primary prevention of venous thrombosis. |
| Databáze: | OpenAIRE |
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