Cellular Reprogramming—A Model for Melanoma Cellular Plasticity
| Autor: | Juliane Poelchen, Jochen Utikal, Karol Granados, Daniel Novak |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cell Plasticity
Induced Pluripotent Stem Cells cellular plasticity Review Biology Models Biological Catalysis lcsh:Chemistry Inorganic Chemistry Cell Line Tumor melanoma medicine Animals Humans Physical and Theoretical Chemistry Induced pluripotent stem cell lcsh:QH301-705.5 Molecular Biology Spectroscopy Genetic heterogeneity Melanoma Organic Chemistry Cancer Cell Differentiation General Medicine Cellular Reprogramming medicine.disease Phenotype Computer Science Applications Gene Expression Regulation Neoplastic partial reprogramming lcsh:Biology (General) lcsh:QD1-999 Tumor progression phenotype switch Cancer cell Neoplastic Stem Cells Cancer research heterogeneity Reprogramming |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 8274, p 8274 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Cellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug resistance and thus remains a major challenge for the treatment of melanoma and other types of cancer. Melanoma cells have the capacity to switch their phenotype during tumor progression, from a proliferative and differentiated phenotype to a more invasive and dedifferentiated phenotype. However, the molecular mechanisms driving this phenotype switch are not yet fully understood. Considering that cellular heterogeneity within the tumor contributes to the high plasticity typically observed in melanoma, it is crucial to generate suitable models to investigate this phenomenon in detail. Here, we discuss the use of complete and partial reprogramming into induced pluripotent cancer (iPC) cells as a tool to obtain new insights into melanoma cellular plasticity. We consider this a relevant topic due to the high plasticity of melanoma cells and its association with a strong resistance to standard anticancer treatments. |
| Databáze: | OpenAIRE |
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