Characterization of integrase region polymorphisms in HIV type 1 CRF06_cpx viruses in treatment-naive patients in Estonia
| Autor: | Kristi Huik, Natalia Nikitina, Irja Lutsar, Tõnu Krispin, Jelena Schmidt, Radko Avi, Külliki Ainsalu, Piret Paap, Tõnis Karki, Maarja Sadam |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Estonia Male medicine.medical_treatment Immunology Molecular Sequence Data Integrase inhibitor HIV Infections Drug resistance HIV Integrase Virus Drug Resistance Multiple Viral Virology Raltegravir Potassium medicine Humans HIV Integrase Inhibitors Phylogeny Genetics Recombination Genetic Protease Polymorphism Genetic biology biology.organism_classification Raltegravir Reverse transcriptase HIV Reverse Transcriptase Pyrrolidinones Integrase Infectious Diseases Lentivirus biology.protein HIV-1 RNA Viral Female medicine.drug |
| Zdroj: | AIDS research and human retroviruses. 26(10) |
| ISSN: | 1931-8405 |
| Popis: | Natural polymorphisms of HIV-1, often associated with drug resistance, are widely described in protease and reverse transcriptase regions but data on their presence in the integrase region, especially in non-B subtypes, are still very limited. We aimed to characterize naturally occurring polymorphisms in the integrase region in 104 treatment-naive and 10 treatment-experienced patients infected predominantly with HIV-1 CRF06_cpx and its recombinant with subtype A1 and/or CRF03_AB viruses. No primary drug resistance mutations against integrase inhibitors were found, but resistance-associated polymorphisms such as V72I, L74I, V201I, and T206S were seen in more than 90% of viruses. Substitutions E157Q and E157K, associated with raltegravir resistance, were found in only two CRF06_cpx strains. We conclude that similar to other HIV-1 non-B subtypes, the CRF06_cpx and its recombinants with subtype A1 and CRF03_AB are rich in integrase region natural polymorphisms, which may impact the development of resistance against integrase inhibitors. |
| Databáze: | OpenAIRE |
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