Increasing morbidity and mortality of candidemia over one decade in a Swiss university hospital
| Autor: | Emmanouil Glampedakis, Jean-Luc Pagani, O. Marchetti, Laetitia Kalbermatter, Julien Battistolo, Frédéric Lamoth, Bruno Grandbastien, Julien Poissy, Thierry Calandra, Pierre-Yves Bochud, Philippe Eggimann, Lauro Damonti |
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| Přispěvatelé: | Fungal Infection Network of Switzerland (FUNGINOS) |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antifungal Agents Multivariate analysis Critical Illness 610 Medicine & health Dermatology law.invention Hospitals University Drug Resistance Fungal Risk Factors law Internal medicine Intensive care Epidemiology medicine Humans Aged Candida Retrospective Studies Antifungal Agents/therapeutic use Candidemia/drug therapy Candidemia/epidemiology Candidemia/mortality Incidence Middle Aged Switzerland/epidemiology antifungal resistance blood cultures elderly incidence intensive care unit invasive candidiasis septic shock Septic shock business.industry Incidence (epidemiology) Mortality rate Candidemia Retrospective cohort study General Medicine bacterial infections and mycoses medicine.disease Intensive care unit Infectious Diseases business Switzerland |
| Zdroj: | Battistolo, Julien; Glampedakis, Emmanouil; Damonti, Lauro; Poissy, Julien; Grandbastien, Bruno; Kalbermatter, Laetitia; Pagani, Jean-Luc; Eggimann, Philippe; Bochud, Pierre-Yves; Calandra, Thierry; Marchetti, Oscar; Lamoth, Frederic (2021). Increasing morbidity and mortality of candidemia over one decade in a Swiss university hospital. Mycoses, 64(12), pp. 1512-1520. Wiley-Blackwell 10.1111/myc.13376 Mycoses, vol. 64, no. 12, pp. 1512-1520 |
| ISSN: | 1439-0507 0933-7407 |
| DOI: | 10.1111/myc.13376 |
| Popis: | BACKGROUND The epidemiology of candidemia is evolving with raising concern about the emergence of intrinsically resistant non-albicans Candida species and acquisition of antifungal resistance. In addition to microbiological surveys, epidemiological studies including clinical data are needed to assess the impact of candidemia on morbidity and mortality. OBJECTIVES To assess the clinical and microbiological trends of candidemia in a Swiss university hospital. PATIENTS/METHODS This single-centre retrospective study compared the incidence of candidemia, Candida species distribution, antifungal resistance profiles, clinical characteristics and outcomes between two periods separated by one decade. RESULTS A total of 170 candidemic episodes were included (68 from period 1, 2004-2006, and 102 from period 2, 2014-2017). Incidence of candidemia (0.85 to 0.97 episode/10,000 patient-days), species distribution (55%-57% C albicans) and antifungal susceptibilities remained unchanged. During period 2, candidemia was more frequently observed in intensive care units (ICU, 38% vs 19% in period 1, P��=��.01) and amongst older patients (median age 68 vs 59��years old, P�� |
| Databáze: | OpenAIRE |
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