Prognostic significance of troponin T elevation in patients without chest pain
| Autor: | Dominick J. Angiolillo, Donald A. Conetta, Erik R. Carlson, Robert F. Percy |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Thorax
Male medicine.medical_specialty Creatine Chest pain Infections chemistry.chemical_compound Troponin T Internal medicine Medicine Humans Retrospective Studies biology business.industry Age Factors Retrospective cohort study Emergency department Middle Aged Prognosis Triage Troponin Logistic Models chemistry Case-Control Studies Hypertension Cardiology biology.protein Female medicine.symptom Cardiology and Cardiovascular Medicine business Emergency Service Hospital Gastrointestinal Hemorrhage Follow-Up Studies |
| Zdroj: | The American journal of cardiology. 102(6) |
| ISSN: | 0002-9149 |
| Popis: | Increased cardiac troponin with chest pain is important for the diagnosis, triage, and treatment of patients in the emergency department. However, the use of troponin for the diagnosis and triage of patients without chest pain is poorly established. The aim of this study was to determine 30-day and 1-year mortality and morbidity of troponin T increases in patients without chest pain. This retrospective study compared 92 hospitalized patients without (study group) and 91 patients with chest pain (control group), followed up for 1 year. Study group patients had troponin T0.04 microg/L, normal creatine kinase or creatine kinase-MB fraction5%, and no electrocardiographic ischemia. Excluded were high-risk patients with end-stage kidney disease, those with left ventricular ejection fraction40%, and the critically ill. Outcome variables included 30-day and 1-year death, myocardial infarction, unstable angina, and coronary revascularization rates. Thirty-day (13.0% vs 4.4%; p = 0.032) and 1-year (33% vs 4.6%; p0.001) mortality rates were significantly higher in the study group, whereas myocardial infarction, unstable angina, and revascularization were infrequent. In conclusion, patients with increased troponin T and no chest pain had a high mortality rate and required careful follow-up. |
| Databáze: | OpenAIRE |
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