Oral bioavailability and pharmacokinetics of baquiloprim in dwarf goats
| Autor: | A. S. J. P. A. M. van Miert, Renger F. Witkamp, R.F.M. Maas, J Lewicki |
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| Rok vydání: | 1995 |
| Předmět: |
Volume of distribution
General Veterinary Chemistry Goats Cmax Administration Oral Biological Availability Absorption (skin) Dwarf goats Pharmacology Bioavailability Pyrimidines Animal science Pharmacokinetics Injections Intravenous Animals Distribution (pharmacology) Female Dosing Chromatography High Pressure Liquid |
| Zdroj: | Research in Veterinary Science. 58:268-271 |
| ISSN: | 0034-5288 |
| DOI: | 10.1016/0034-5288(95)90115-9 |
| Popis: | The pharmacokinetics of baquiloprim at a dose of 8 mg kg --l bodyweight were determined after its intravenous and intra-ruminal administration to seven healthy female dwarf goats. After intravenous injection, the plasma elimination curve showed a rapid distribution phase (mean [ sd ] t 1 2α 0·89 [0·4] hours). The mean volume of distribution at steady-state (Vdss) was 14·1 (2·7) litres kg−1 bodyweight. The mean elimination half-life ( t 1 2β ) was 14·0 (2·3) hours. After intra-ruminal administration its maximum concentration in plasma (Cmax) was 0·09 (0·01 μg ml−1 and this maximum was not reached until approximately 35 hours after administration. The systemic oral bioavailability, calculated up to 48 hours after dosing, was 33·7 (7·1) per cent. Owing to a prolonged absorption phase, the data from only four of the goats fitted reasonably to a compartmental model. |
| Databáze: | OpenAIRE |
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