Conditioned medium from umbilical cord mesenchymal stem cells improves nasal mucosa damage by radiation
| Autor: | Chun-Quan Zheng, Jing Wang, Hong-Gang Duan, Jing Li, Fang Ji |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Guinea Pigs Bioengineering Mucous membrane of nose Applied Microbiology and Biotechnology Umbilical cord Umbilical Cord 03 medical and health sciences 0302 clinical medicine Cell Movement In vivo medicine Animals Humans Cilia Radiation Injuries Cells Cultured Cell Proliferation Chemistry Mesenchymal stem cell Mesenchymal Stem Cells General Medicine respiratory system Mucus Epithelium In vitro Nasal Mucosa 030104 developmental biology medicine.anatomical_structure Culture Media Conditioned 030220 oncology & carcinogenesis Female Nasal administration Biotechnology |
| Zdroj: | Biotechnology Letters. 40:999-1007 |
| ISSN: | 1573-6776 0141-5492 |
| Popis: | To explore therapeutic effects of conditioned medium from human umbilical cord mesenchymal stem cells (hUC-MSCs) on nasal mucosa radiation damage both in vivo and in vitro. The mucus cilia clearance time (7 and 30 days), degree of mucosal edema (7, 30, 90 and 180 days), cilia coverage (180 days) of concentrated conditioned medium group improved compared with radiotherapy control group. The proliferation and migration abilities of irradiated and non-irradiated nasal epithelial cells significantly increased after culture in bronchial epithelial cell growth medium (BEGM) containing 10% conditioned medium of hUC-MSCs compared to cells cultured in BEGM alone. Soluble factors secreted by hUC-MSCs may promote nasal epithelial cell proliferation and migration. Intranasal administration of hUC-MSC conditioned medium effectively repairs nasal mucosa radiation damage. |
| Databáze: | OpenAIRE |
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