The microRNA-dependent cell fate of multipotent stromal cells differentiating to endothelial cells
| Autor: | Ki-Chul Hwang, Byeong-Wook Song, Cheesoon Yoon, Seahyoung Lee, Eunhyun Choi, Min-Ji Cha |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell type Stromal cell Cellular differentiation Mesenchymal stem cell Endothelial Cells Bone Marrow Cells Cell Differentiation Mesenchymal Stem Cells Cell Biology Biology Cell fate determination Cell biology Rats Sprague-Dawley MicroRNAs 03 medical and health sciences 030104 developmental biology Growth factor receptor microRNA Immunology Animals Cell Lineage Signal transduction Cells Cultured Signal Transduction |
| Zdroj: | Experimental Cell Research. 341:139-146 |
| ISSN: | 0014-4827 |
| DOI: | 10.1016/j.yexcr.2016.02.005 |
| Popis: | In the endothelial recovery process, bone marrow-derived MSCs are a potential source of cells for both research and therapy, and their capacities to self-renew and to differentiate into all the cell types in the human body make them a promising therapeutic agent for remodeling cellular differentiation and a valuable resource for the treatment of many diseases. Based on the results provided in a miRNA database, we selected miRNAs with unique targets in cell fate-related signaling pathways. The tested miRNAs targeting GSK-3β (miR-26a), platelet-derived growth factor receptor, and CD133 (miR-26a and miR-29b) induced MSC differentiation into functional ECs, whereas miRNAs targeting VEGF receptor (miR-15, miR-144, miR-145, and miR-329) inhibited MSC differentiation into ECs through VEGF stimulation. In addition, the expression levels of these miRNAs were correlated with in vivo physiological endothelial recovery processes. These findings indicate that the miRNA expression profile is distinct for cells in different stages of differentiation from MSCs to ECs and that specific miRNAs can function as regulators of endothelialization. |
| Databáze: | OpenAIRE |
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