Prognosis Factors and Outcomes of Neuro-ophthalmologic Sarcoidosis
| Autor: | Mathilde Leclercq, Antoine Gueguen, David Saadoun, Valérie Touitou, Natalia Shor, Bahram Bodaghi, Anne Claire Desbois, Catherine Chapelon-Abric, Thomas Sené, Catherine Vignal-Clermont, Patrice Cacoub, Fanny Domont, Elisabeth Maillart |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Optic Neuritis Visual acuity Sarcoidosis genetic structures business.industry Prognosis medicine.disease eye diseases Ophthalmology Optic Nerve Diseases medicine Optic nerve Humans Immunology and Allergy Female medicine.symptom business Retrospective Studies |
| Zdroj: | Ocular Immunology and Inflammation. 30:821-828 |
| ISSN: | 1744-5078 0927-3948 |
| Popis: | Neuro-ophthalmologic manifestations are uncommon in sarcoidosis. We aim to assess the prognostic factors and outcome of neuro-ophthalmic sarcoidosis.We conducted a multicenter retrospective study on patients with neuro-ophthalmic sarcoidosis. Response to therapy was based on visual acuity, visual field, and orbital MRI exam. Factors associated with remission and relapse were analyzed.Thirty-five patients [median (IQR) age of 37 years (26.5-53), 63% of women] were included. The diagnosis of sarcoidosis was concomitant of neuro-ophthalmologic symptoms in 63% of cases. Optic neuritis was the most common manifestation. All patients received corticosteroids and 34% had immunosuppressants. At 6 months, 61% improved, 30% were stable, and 9% worsened. Twenty percent of patients had severe visual deficiency at the end of follow-up. Nonresponders patients had significantly worse visual acuity at baseline (Prognosis of neuro-ophthalmic sarcoidosis is poor. |
| Databáze: | OpenAIRE |
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