Isotopic evaluation and therapy in patients with malignant endocrine disease
| Autor: | Susan E.M. Clarke, Val Lewington |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty Endocrine disease business.industry Endocrinology Diabetes and Metabolism Tumour targeting Malignancy medicine.disease Bioinformatics Endocrinology Endocrine Gland Neoplasms Metabolic markers medicine Humans Endocrine system Disseminated disease In patient Radionuclide imaging Radionuclide Imaging business |
| Zdroj: | Best Practice & Research Clinical Endocrinology & Metabolism. 15:225-239 |
| ISSN: | 1521-690X |
| DOI: | 10.1053/beem.2001.0137 |
| Popis: | The contribution of nuclear medicine to the diagnosis and treatment of endocrine malignancy is increasing. Advances in molecular biology offer new opportunities for tumour targeting via surface receptor recognition and tumour-specific metabolic markers. Imaging the biodistribution of these markers allows quantitative, in vivo characterization of tumour function. There is growing interest in the therapeutic potential of nuclear medicine targeting, substituting therapeutic beta-emitting radionuclides for the gamma-emitters used in diagnostic imaging. Limited clinical experience supports the rationale of this approach in patients with inoperable or disseminated disease and controlled trials are in progress. This chapter outlines the place of nuclear medicine techniques in the routine management of endocrine malignancy and explores areas for further development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect