Pyridoxine-induced toxicity in rats: A stereological quantification of the sensory neuropathy
Autor: | Nigel H. Greig, Harold W. Holloway, Tracy Ann Perry, Ananda Weerasuriya, Peter R. Mouton |
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Rok vydání: | 2004 |
Předmět: |
Male
Pathology medicine.medical_specialty Neural Conduction Sensory system Cell Count Nerve Fibers Myelinated H-Reflex Rats Sprague-Dawley Developmental Neuroscience Dorsal root ganglion Ganglia Spinal medicine Animals Cell Size Motor Neurons business.industry Pyridoxine Neurodegenerative Diseases Sciatic Nerve Pathophysiology Rats Electrophysiology Disease Models Animal medicine.anatomical_structure Neurology nervous system Toxicity Sensation Disorders Disease Progression Sciatic nerve H-reflex business Neuroscience Psychomotor Performance medicine.drug |
Popis: | Excess ingestion of pyridoxine (vitamin B6) causes a severe sensory neuropathy in humans. The mechanism of action has not been fully elucidated, and studies of pyridoxine neuropathy in experimental animals have yielded disparate results. Pyridoxine intoxication appears to produce a neuropathy characterized by necrosis of dorsal root ganglion (DRG) sensory neurons and degeneration of peripheral and central sensory projections, with large diameter neurons being particularly affected. The major determinants affecting the severity of the pyridoxine neuropathy appear to be duration and dose of pyridoxine administration, differential neuronal vulnerability, and species susceptibility. The present study used design-based stereological techniques in conjunction with electrophysiological measures to quantify the morphological and physiological changes that occur in the DRG and the distal myelinated axons of the sciatic nerve following pyridoxine intoxication. This combined stereological and electrophysiological method demonstrates a general approach that could be used for assessing the correlation between pathophysiological and functional parameters in animal models of toxic neuropathy. |
Databáze: | OpenAIRE |
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