Abnormal retinal artery responses to stress in patients with type I diabetes
| Autor: | Thomas M. O'Dorisio, Philip G. Fields, Samuel Cataland, Jack M. George, Kwame Osei, Elson L. Craig |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty Brachial Artery Retinal Artery Blood Pressure chemistry.chemical_compound Diabetic Neuropathies Stress Physiological Internal medicine medicine.artery Diabetes mellitus Humans Medicine Brachial artery Pulse Glycemic Diabetic Retinopathy business.industry Cold pressor test Retinal General Medicine Diabetic retinopathy medicine.disease Cold Temperature Diabetes Mellitus Type 1 Blood pressure Endocrinology Autonomic Nervous System Diseases chemistry Hypertension Cardiology Ophthalmodynamometry Female business |
| Zdroj: | The American Journal of Medicine. 78:595-601 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(85)90401-2 |
| Popis: | The brachial artery pressure and retinal artery pressure responses to a one-minute cold pressor test were evaluated simultaneously in 14 patients with type I diabetes mellitus (six with and eight without diabetic retinopathy) and 10 age-matched control subjects. Five patients with type I diabetes had autonomic neuropathy. Mean baseline brachial artery pressure and retinal artery pressure were similar in patients with type I diabetes and control subjects. After cold pressor testing, the brachial artery pressure increased significantly (p less than 0.01) compared with baseline values in both groups. Retinal mean arterial pressures increased significantly (p less than 0.001) after cold pressor testing compared with the baseline values only in patients with type I diabetes. Positive correlation was found between the brachial and retinal mean arterial pressures after cold pressor testing (r = 0.48; p less than 0.05) in the diabetic patients but not in the control subjects (r = 0.10; p = NS). No correlation was found between the retinal artery pressure and age of onset of diabetes, duration of diabetes, the presence or absence of diabetic retinopathy, and glycemic control. Four patients with autonomic neuropathy and low retinal artery pressures, which remained unchanged after cold pressor testing, had no diabetic retinopathy. The fifth patient with autonomic neuropathy and exaggerated systolic brachial artery pressure (175 mm Hg) and retinal artery pressure (more than 80 mm Hg) responses had severe background diabetic retinopathy. In conclusion, abnormal retinal artery responses to stress are present in patients with type I diabetes. This may be modified by the presence or absence of both autonomic neuropathy and hypertension. The biologic significance of these findings is yet to be determined. |
| Databáze: | OpenAIRE |
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