astray , a Zebrafish roundabout Homolog Required for Retinal Axon Guidance

Autor:	Cornelia Fricke, Jeong-Soo Lee, Chi-Bin Chien, Friedrich Bonhoeffer, Silke Geiger-Rudolph
Rok vydání:	2001
Předmět:	Male Retinal Ganglion Cells Superior Colliculi Eye transplantation Nerve Tissue Proteins Biology Eye Retinal ganglion Retina medicine Animals Visual Pathways Receptors Immunologic Axon Zebrafish Alleles Crosses Genetic In Situ Hybridization Body Patterning Multidisciplinary Chromosome Mapping Gene Expression Regulation Developmental Anatomy Zebrafish Proteins biology.organism_classification Axons Transplantation Phenotype medicine.anatomical_structure Genes nervous system Mutation Roundabout Female Axon guidance Neuroscience
Zdroj:	Science. 292:507-510
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.1059496
Popis:	As growing retinotectal axons navigate from the eye to the tectum, they sense guidance molecules distributed along the optic pathway. Mutations in the zebrafish astray gene severely disrupt retinal axon guidance, causing anterior-posterior pathfinding defects, excessive midline crossing, and defasciculation of the retinal projection. Eye transplantation experiments show that astray function is required in the eye. We identify astray as zebrafish robo2 , a member of the Roundabout family of axon guidance receptors. Retinal ganglion cells express robo2 as they extend axons. Thus, robo2 is required for multiple axon guidance decisions during establishment of the vertebrate visual projection.
Databáze:	OpenAIRE
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