Exploring the Association between Severe Respiratory Syncytial Virus Infection and Asthma. A Registry-based Twin Study
| Autor: | Lone Graff Stensballe, Vibeke Backer, Danielle Posthuma, Sophie van der Sluis, Hans Bisgaard, David L. Duffy, Kirsten Ohm Kyvik, Axel Skytthe, Simon Francis Thomsen |
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| Přispěvatelé: | Human genetics, Biological Psychology, Functional Genomics |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Denmark Population Twins Enzyme-Linked Immunosorbent Assay Respiratory Syncytial Virus Infections Critical Care and Intensive Care Medicine Virus SDG 3 - Good Health and Well-being Risk Factors Internal medicine Intensive care medicine Humans Registries Respiratory system education Child Antigens Viral Asthma Retrospective Studies education.field_of_study business.industry Incidence Respiratory disease Models Theoretical medicine.disease Prognosis Twin study respiratory tract diseases Hospitalization Child Preschool Respiratory Syncytial Virus Human Immunology Female Viral disease business Follow-Up Studies |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine, 179(12), 1091-1097. American Thoracic Society Thomsen, S F, van der Sluis, S, Stensballe, L G, Posthuma, D, Skytthe, A, Kyvik, K O, Duffy, DL, Backer, V & Bisgaard, H 2009, ' Exploring the Association between Severe Respiratory Syncytial Virus Infection and Asthma. A Registry-based Twin Study ', American Journal of Respiratory and Critical Care Medicine, vol. 179, no. 12, pp. 1091-1097 . https://doi.org/10.1164/rccm.200809-1471OC Thomsen, S F, Sluis, S V D, Stensballe, L G, Posthuma, D, Skytthe, A, Kyvik, K O, Duffy, D L, Backer, V & Bisgaard, H 2009, ' Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study ', American Journal of Respiratory and Critical Care Medicine, vol. 179, no. 12, pp. 1091-7 . https://doi.org/10.1164/rccm.200809-1471OC |
| ISSN: | 1073-449X |
| Popis: | Rationale: Severe respiratory syncytial virus (RSV) infection is associated with asthma but the nature of this association is imperfectly understood. Objectives: To examine the nature of the association between severe RSV infection and asthma in a population-based sample of twins. Methods: Data on hospitalization due to RSV infection was gathered for all twins born in Denmark between 1994 and 2000 (8,280 pairs) and linked to information on asthma obtained from hospital discharge registries and parent-completed questionnaires. Genetic variance components models and direction of causation models were fitted to the observed data. Measurements and Main Results: RSV hospitalization and asthma were positively associated (r = 0.43), and genetic determinants for the two disorders overlapped completely. Modeling the direction of causation between RSV hospitalization and asthma showed that a model in which asthma "causes" RSV hospitalization fitted the data significantly better (P = 0.39 for deterioration in model fit) than a model in which RSV hospitalization "causes" asthma (P < 0.001 for deterioration in model fit), even when sex, birth weight, and maternal smoking during pregnancy were accounted for. Conclusions: RSV infection that is severe enough to warrant hospitalization does not cause asthma but is an indicator of the genetic predisposition to asthma. |
| Databáze: | OpenAIRE |
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