Reduction of fever by housing in small cages
| Autor: | Gernot Kuhnen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Lipopolysaccharides
Male Restraint Physical Veterinary medicine Fever Core temperature Biology Stress level Body Temperature Rodent Diseases Random Allocation Animal science Animals Laboratory Cricetinae Animals General Veterinary Mesocricetus Salmonella typhosa Salmonella typhi Housing Animal Defence response Animal Science and Zoology Injections Intraperitoneal Stress Psychological Golden hamster Cage size |
| Zdroj: | Laboratory animals. 32(1) |
| ISSN: | 0023-6772 |
| Popis: | Housing conditions influence anatomy, physiology, and behaviour of animals. The aim of this study is to investigate whether the generation of fever, a defence response of the body, is also affected by housing conditions. Golden hamsters ( Mesocricetus auratus) were housed in small cages, large cages, or large and enriched cages. After 9 weeks of exposure to their respective environments, the fever response to the administration of lipopolysaccharide (50 μg/kg from Salmonella typhosa) was tested. One hundred and twenty experiments in 30 hamsters demonstrated that housing in small cages diminished the fever responses (increase in core temperature and fever index) significantly by approximately 20%, and is likely to be due to a higher stress level. The findings demonstrate that the results of physiological experiments are not only influenced by the experimental design, but also by pre-experimental housing conditions. |
| Databáze: | OpenAIRE |
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