The Thalamocortical Circuit of Auditory Mismatch Negativity
| Autor: | Peter Lakatos, Samuel A. Neymotin, Annamaria Barczak, Daniel C. Javitt, Monica N. O'Connell, Charles E. Schroeder, Tammy McGinnis, John F. Smiley |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Auditory Cortex Thalamus Mismatch negativity Brain Cognition Sensory system Electroencephalography Stimulus (physiology) Biology Auditory cortex behavioral disciplines and activities Nonhuman primate 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Acoustic Stimulation Auditory Perception Evoked Potentials Auditory Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery Biological Psychiatry |
| Zdroj: | Biological psychiatry. 87(8) |
| ISSN: | 1873-2402 |
| Popis: | Background Mismatch negativity (MMN) is an extensively validated biomarker of cognitive function across both normative and clinical populations and has previously been localized to supratemporal auditory cortex. MMN is thought to represent a comparison of the features of the present stimulus versus a mnemonic template formed by the prior stimuli. Methods We used concurrent thalamic and primary auditory cortical (A1) laminar recordings in 7 macaques to evaluate the relative contributions of core (lemniscal) and matrix (nonlemniscal) thalamic afferents to MMN generation. Results We demonstrated that deviance-related activity is observed mainly in matrix regions of auditory thalamus, MMN generators are most prominent in layer 1 of cortex as opposed to sensory responses that activate layer 4 first and sequentially all cortical layers, and MMN is elicited independent of the frequency tuning of A1 neuronal ensembles. Consistent with prior reports, MMN-related thalamocortical activity was strongly inhibited by ketamine. Conclusions Taken together, our results demonstrate distinct matrix versus core thalamocortical circuitry underlying the generation of a higher-order brain response (MMN) versus sensory responses. |
| Databáze: | OpenAIRE |
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