Lack of association between carotid intima-media thickness and apolipoprotein (a) isoforms in a sample of Spanish general population
| Autor: | Carlos Lapresta, Pilar Calmarza, Pilar López, José María Trejo |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Gene isoform
Adult Male medicine.medical_specialty Multivariate analysis Apolipoprotein B Carotid arteries Population Early atherosclerosis Apoprotein(a) Carotid Intima-Media Thickness White People Random Allocation Internal medicine Lipoprotein (a) Medicine Humans Protein Isoforms cardiovascular diseases education Aged Aged 80 and over education.field_of_study biology business.industry Lipoprotein(a) Middle Aged Atherosclerosis Intima media thickness Intima-media thickness Apolipoprotein (a) phenotypes Spain Multivariate Analysis biology.protein Cardiology cardiovascular system Female business Cardiology and Cardiovascular Medicine Carotid artery Lipoprotein |
| Zdroj: | Journal of Cardiology. 61(5):372-377 |
| ISSN: | 0914-5087 |
| DOI: | 10.1016/j.jjcc.2013.01.006 |
| Popis: | Objectives The purpose of this study was to examine the relationship between apolipoprotein (a) isoforms and early atherosclerosis, assessed by carotid artery intima-media thickness in a sample of adults of the general population of Burgos, a city in the north of Spain. Design and methods Lipids, lipoprotein (a), number of carotid atherosclerotic plaques, if any, and the intima-media thickness in the far wall of both common carotid arteries by B-mode ultrasound were determined in a group of 171 adults from the general population of Burgos, Spain. Apolipoprotein (a) isoforms were determined in a random subset of 119 subjects. Results Increasing age, male sex, and past personal cardiovascular history were significantly associated with increased left, right, or average intima-media thickness of both carotid arteries in multivariate analysis. No statistically significant association was found between apolipoprotein (a) isoforms and mean carotid intima-media thickness by bivariate or multivariate regression analysis. Conclusions In this sample of the general Spanish population, no association was found between apolipoprotein (a) isoforms and carotid artery intima-media thickness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect