Minocycline and Magnesium As Neuroprotective Agents for Ischemic Stroke: A Systematic Review
| Autor: | Ignacio Córdova, Juan Fernando Ortiz, Mohammad R Ghani, Farah Bashir, Gustavo Moya, Alisha Saxena, Álvaro Morillo Cox, Willians Tambo, Samir Ruxmohan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry General Engineering Ischemia Minocycline magnesium 030204 cardiovascular system & hematology medicine.disease stroke Tissue plasminogen activator Neuroprotection Clinical trial 03 medical and health sciences minocycline 0302 clinical medicine Neurology Internal medicine medicine Dementia cardiovascular diseases business Stroke 030217 neurology & neurosurgery medicine.drug Cause of death |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Stroke is a leading cause of death, disability, and dementia worldwide. Strokes can be divided into ischemic strokes and hemorrhagic strokes. At the moment, tissue plasminogen activator (tPA) is the only FDA-approved drug for ischemic stroke. Minocycline (MC) and Magnesium (Mg) are promising therapies for ischemic stroke, especially in the pre-hospital setting. These drugs are readily available, inexpensive, and generally safe. We decided to investigate these drugs' neuroprotective effects in treating ischemic stroke in the acute and chronic setting. We conducted a systematic review of the published literature on MC and Mg's functional outcome in ischemic stroke. This paper's methodology included only clinical trials published in the last 15 years, using PubMed as a database. The systematic review demonstrated that MC infusion in the pre-hospital and hospital setting improved functional outcomes and disability scores. Furthermore, MC also decreased matrix metalloproteinase 9 (MMP-9) levels. MC might have a more significant effect on men than women because different molecular pathways of cerebral ischemia seem to be involved between both genders. The systematic review showed that patients with ischemic stroke did not benefit from magnesium sulfate infusion in the pre-hospital and hospital setting. Nevertheless, patients with lacunar strokes and patients who supplemented their meals with potassium-magnesium salt in the diet had better functional outcomes. Future studies would need a more significant sample of participants and a better selection to increase the study's power and avoid selection bias, respectively. Further publications could benefit from subcategorizing strokes and investigating the gender role in stroke treatment. These directives could give a more robust conclusion regarding the neuroprotective effects of these drugs. |
| Databáze: | OpenAIRE |
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