Photodynamic therapy in wound healing in vivo: a systematic review
| Autor: | Maria Valdrinez Campana Lonardoni, Izabel Galhardo Demarchi, Jorge Juarez Vieira Teixeira, Jully Oyama, Sandra Mara Alessi Aristides, Thaís Gomes Verzignassi Silveira, Vanessa Nesi-Reis, Daniele Stéfanie Sara Lopes Lera-Nonose, Áquila Carolina Fernandes Herculano Ramos-Milaré |
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| Rok vydání: | 2020 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus medicine.drug_class medicine.medical_treatment 030303 biophysics Antibiotics Biophysics Photodynamic therapy Dermatology Bioinformatics 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine In vivo Animals Humans Medicine Effective treatment Pharmacology (medical) Wound treatment Wound Healing 0303 health sciences Photosensitizing Agents integumentary system business.industry Regeneration (biology) Tissue repair Photochemotherapy Oncology business Wound healing |
| Zdroj: | Photodiagnosis and Photodynamic Therapy. 30:101682 |
| ISSN: | 1572-1000 |
| DOI: | 10.1016/j.pdpdt.2020.101682 |
| Popis: | Wounds constitute severe problems in public health. Inappropriate manipulation to promote wound healing and indiscriminate use of antibiotics may contribute to failure in wound treatment, leading to bacterial growth and resistance. Appropriate and correct approaches to wound treatment are crucially important. Further, the development of new and effective treatment modalities is important to decrease infection-related mortality and to reduce patient suffering and side effects. Photodynamic therapy (PDT) could be a promising approach to ameliorate this global health problem. We researched articles that used PDT in wound healing in vivo. The systematic review included articles that investigated the effect of PDT on wound healing in animals, published from May 2008 through 2018, in the databases PubMed and Web of Science. The main types of wounds described in the selected articles were burns, abrasions, and excisional wounds. Most of the studies tested PDT in wounds infected by methicillin-resistant Staphylococcus aureus, S. aureus standard strain, or Pseudomonas aeruginosa. The studies demonstrated that PDT contributes in several ways to the wound healing process, such as killing bacterial cells and stimulating the proliferation of fibroblasts and consequently of collagen and elastin. Based on these studies, PDT provided excellent results for the wound healing process, acting in several steps and accelerating tissue repair. PDT has proven to be a promising therapeutic modality, able to inhibit bacterial regrowth or kill bacteria, contributing significantly to accelerate the wound healing process. |
| Databáze: | OpenAIRE |
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