Analysis of impurities in vertilmicin sulfate by liquid chromatography ion-trap mass spectrometry
| Autor: | Mei Zhang, Shao-hong Jin, Erwin Adams, Jos Hoogmartens, Ann Van Schepdael, Chang-qin Hu, Yaozuo Yuan, Fan Xialei |
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| Rok vydání: | 2013 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Aqueous solution Chromatography Chemistry Electrospray ionization Clinical Biochemistry Analytical chemistry Pharmaceutical Science Hydrogen-Ion Concentration Mass spectrometry Anti-Bacterial Agents Analytical Chemistry Ion chemistry.chemical_compound Aminoglycosides Liquid chromatography–mass spectrometry Impurity Phase (matter) Drug Discovery Sulfate Drug Contamination Spectroscopy Chromatography Liquid |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 80:1-8 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/j.jpba.2013.02.026 |
| Popis: | The characterization of impurities present in vertilmicin by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. A reversed phase (RP)-LC method using a C18 column resistant to basic pH with an alkaline (pH 11) aqueous mobile phase was developed and coupled to MS with an electrospray ionization (ESI) source in the positive ion mode which provides MSn capability. In total, 18 impurities were detected in a commercial sample. Eleven impurities described in this work were newly identified. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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