‘FLT3-ITD Mutation Does Not Influence Survival Outcome in Adult Acute Promyelocytic Leukemia Patients Treated With ATO and ATRA-Based Therapeutic Regimen: Experience From a North Indian Tertiary Care Centre’

Autor:	Riju Rani Deka, Shano Naseem, Prateek Bhatia, Jogeshwar Binota, Preeti Sonam, Palak Rana, Pankaj Malhotra, Neelam Varma
Rok vydání:	2022
Předmět:	Adult Male Cancer Research Adolescent Nuclear Proteins Hematology Prognosis Tertiary Care Centers Leukemia Myeloid Acute Young Adult Leukemia Promyelocytic Acute fms-Like Tyrosine Kinase 3 Oncology Mutation Humans Female
Zdroj:	Clinical Lymphoma Myeloma and Leukemia. 22:416-423
ISSN:	2152-2650
Popis:	NPM1 and FLT3-ITD are frequently mutated genes in acute myeloid leukemia. We studied clinico-hematological profile and survival outcome of adult acute promyelocytic leukemia (APL) patients harboring these mutations.De novo APL cases (12 years), enrolled between January 2019 and June 2020, were evaluated for FLT3-ITD and NPM1 mutations (A, B, D mutations) by conventional and real-time qualitative PCR respectively.FLT3-ITD mutation was detected in 12 of 36 (33.3%) de novo APLs cases while NPM1 mutation was not detected. FLT3-ITD was more frequently associated with Sanz high-risk category as compared to the intermediate-risk category (75% vs. 29%, P = .02), with BCR3 transcript type (P = .08) and higher median WBC count [22.7 × 10FLT3-ITD mutation did not influence survival outcome in adult APL treated with ATO and ATRA-based therapeutic regimen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20caea9532452de59607293afcf1ea56 https://doi.org/10.1016/j.clml.2021.12.007 Zobrazit plný text záznamu Full Text from ScienceDirect