Bacterial Infections and Osteoclastogenesis Regulators in Men and Women with Cholesteatoma
| Autor: | Ryszard Wiaderkiewicz, Włodzimierz Dziubdziela, Wirginia Likus, Anna Kostrząb-Zdebel, Jarosław Markowski, Krzysztof Siemianowicz, Jan Wiaderkiewicz, Edyta Jura-Szołtys, Marek J. Łos |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male musculoskeletal diseases 0301 basic medicine Staphylococcus aureus Immunology Osteoclasts Pilot Projects medicine.disease_cause Bone and Bones Bone remodeling 03 medical and health sciences 0302 clinical medicine Osteoprotegerin Osteogenesis otorhinolaryngologic diseases medicine Humans Immunology and Allergy Middle Ear Cholesteatoma Cholesteatoma 030223 otorhinolaryngology Mycosis Inflammation Receptor Activator of Nuclear Factor-kappa B biology business.industry RANK Ligand Bacterial Infections Gene Expression Regulation Bacterial General Medicine Middle Aged medicine.disease Immunohistochemistry 030104 developmental biology medicine.anatomical_structure RANKL Pseudomonas aeruginosa Middle ear biology.protein Female business |
| Zdroj: | Archivum Immunologiae et Therapiae Experimentalis. 64:241-247 |
| ISSN: | 1661-4917 0004-069X |
| Popis: | One of the most distinct features of middle ear cholesteatoma is bone destruction. Aetiology of cholesteatoma is thought to be multifactorial. Endotoxins produced by bacteria are thought to initiate the inflammation process in the middle ear leading to cholesteatoma. There are physiological differences in bone metabolism between men and women. The aim of our study was the immunohistochemical evaluation of the contents of two key components of the OPG/RANK/RANKL triad-RANKL and OPG in cholesteatoma, to analyse if there are any differences between the sexes and to evaluate the bacteria species isolated from cholesteatoma just before surgical treatment and to evaluate their plausible influence on the expression of OPG and RANKL in cholesteatoma. Twenty-one adult patients with acquired cholesteatoma who underwent surgery were analysed. There were no statistically significant differences in the expression of both regulators of osteoclastogenesis between the sexes. In 38.1 % patients cholesteatoma was not infected, whereas in 61.9 % patients various bacterial infections or mycosis were found. The most frequently isolated species was Pseudomonas aeruginosa (14.29 % infections) followed by Staphylococcus aureus (9.52 % infections). There were no statistically significant differences in expression of both OPG and RANKL between uninfected and infected cholesteatomas. |
| Databáze: | OpenAIRE |
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