Bioprosthesis in aortic valve replacement

Autor: Huitzilihuitl Saucedo-Orozco, Jesus Vargas-Barron, Ricardo Márquez-Velazco, Julio Iván Farjat-Pasos, Karla Susana Martinez-Zavala, Valentin Jiménez-Rojas, Sergio Andres Criales-Vera, Jose Antonio Arias-Godínez, Giovanni Fuentevilla-Alvarez, Veronica Guarner-Lans, Israel Perez-Torres, Gabriela Melendez-Ramirez, Tomas Efrain Sanchez Perez, Maria Elena Soto
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Open Heart. BMJ PUBLISHING GROUP
ISSN: 2053-3624
Popis: BackgroundThe evaluation of long-term inflammatory response and function in postoperative patients with aortic valve replacement (AVR) deserves special analysis because it is important to try to prevent reoperation and improve durability and functionality of the prostheses. It is our objectiveMethodsIn this study, we included a cohort of patients with aortic valve damage treated by AVR with mechanical prosthesis, bio prosthesis and we included a control group.ResultsWe found that IL-4 and osteopontin levels were higher in patients with mechanical vs biological prostheses (p=0.01 and p=0.04, respectively), osteoprotegerin (OPG) levels were decreased (p=0.01), women had lower levels of ET-1 and IL-6, (p=0.02) (p=0.04), respectively. Patients older than 60 years had decreased levels of IL-1ß pConclusionsThe findings provide us with the opportunity to effectively treat patients with AVR in the postoperative period, which could prolong the functionality of the bio prostheses.Trial registration numberNCT04557345.
Databáze: OpenAIRE