Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia
| Autor: | El Wui Loh, Yu Chung Lin, Ming Shun Chung, Fang Rong Chang, Chieh Nan Lin, Wen Chen Ouyang, Shu hua Shen, Hsien Jane Chiu, Albert C. Yang |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Psychosis Taiwan Blood Pressure Autonomic Nervous System Electrocardiography Heart Rate Internal medicine medicine Humans Autonomic dysregulation Heart rate variability Psychiatry Triglycerides Biological Psychiatry Metabolic Syndrome Psychopathology Middle Aged medicine.disease Psychiatry and Mental health C-Reactive Protein Blood pressure Schizophrenia Case-Control Studies Linear Models Metabolome Cardiology Female Analysis of variance Metabolic syndrome Lipoproteins HDL Psychology |
| Zdroj: | Psychiatry Research. 210:710-715 |
| ISSN: | 0165-1781 |
| Popis: | Schizophrenia has been associated with autonomic dysregulation and increased cardiovascular co-morbidity. We hypothesised that autonomic dysregulation in patients with schizophrenia is associated with psychopathology and metabolic profiles. In this study, we aimed to evaluate psychopathology, comprehensive metabolic profiles and cardiac autonomic function using heart-rate variability (HRV) analysis in patients with schizophrenia. A total of 94 patients with schizophrenia and 51 healthy controls were recruited. Each patient underwent a physical examination, laboratory tests and rating scale evaluation, and all subjects underwent a 1-h electrocardiogram monitoring. Analysis of variance was used to compare demographic and HRV variables between control and patient groups. We applied multiple regression analysis with backward selection to examine the association between HRV indices and demographic, metabolic and psychopathology profiles. A decreased HRV was found in patient groups, compared to controls. Reduced vagal-related and complexity domain of HRV indices in patient groups were correlated with increased body mass indices, diastolic pressure, triglycerides, high- and low-density lipoprotein and severity of psychosis mainly in the negative symptom domain. This study provides evidence that altered autonomic function is associated with both psychopathology and metabolic profiles in patients with schizophrenia. These findings may warrant future research in using HRV as objective markers to monitor cardiovascular health and the severity of psychosis in patients with schizophrenia. |
| Databáze: | OpenAIRE |
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