Maternal vascular malformation in the placenta is an indicator for fetal growth restriction irrespective of neonatal birthweight

Autor: N.O. Alers, M. Spaanderman, M. Hendrix, C. Severens‐Rijvers, Judith A P Bons, Salwan Al-Nasiry
Přispěvatelé: Promovendi ODB, Obstetrie & Gynaecologie, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA CDL Algemeen (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, MUMC+: MA Arts Assistenten Obstetrie Gynaecologie (9), Pathologie, MUMC+: DA Pat Pathologie (9), RS: GROW - R2 - Basic and Translational Cancer Biology, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Placenta Diseases
Vascular Malformations
Placenta pathology
PREDICTION
Placenta
Cohort Studies
0302 clinical medicine
FOR-GESTATIONAL-AGE
Medicine
Birth Weight
RISK
OUTCOMES
030219 obstetrics & reproductive medicine
Fetal Growth Retardation
ARTERY DOPPLER
Obstetrics
Vascular malformation
Fetal growth restriction
Pregnancy Outcome
Obstetrics and Gynecology
Maternal vascular malperfusion
MALPERFUSION
Prognosis
PREECLAMPSIA
medicine.anatomical_structure
PREGNANCY
Infant
Small for Gestational Age
Female
Analysis of variance
Adult
medicine.medical_specialty
Adolescent
Pregnancy Complications
Cardiovascular
Gestational Age
Ultrasonography
Prenatal
Preeclampsia
03 medical and health sciences
Young Adult
Post-hoc analysis
Ultrasound
Humans
Birth weight centile
Retrospective Studies
Pregnancy
business.industry
MORTALITY
Infant
Newborn
Retrospective cohort study
medicine.disease
ANTIANGIOGENIC FACTORS
030104 developmental biology
Reproductive Medicine
Small for gestational age
business
Developmental Biology
Zdroj: Placenta, 87, 8-15. Elsevier Saunders
ISSN: 0143-4004
Popis: Introduction: To study the association between placental pathology and neonatal birthweight and outcomes, and whether a combination of first trimester biomarkers and fetal growth velocity can predict placental lesions.Methods: The presence of maternal vascular malperfusion (MVM) lesions (Amsterdam criteria) was recorded in a retrospective cohort of singleton pregnancies in the Maastricht University Medical Centre, 2011-2018. First trimester maternal characteristics and PAPP-A, PlGF and sFlt-1 levels were collected. Fetal growth velocities were calculated (mm/week) from 20 to 32 weeks for abdominal circumference, biparietal diameter, head circumference and femur length. Data were compared between neonates with 'small for gestational age' (SGA p50 (reference), using one-way ANOVA and post hoc test.Results: There were significantly more MVM lesions in the SGA group (94.6% p Discussion: Placental MVM lesions correlated inversely with birthweight even in AGA neonates, and was associated with slower fetal growth and more adverse outcome in SGA neonates. A combination of first trimester biomarkers and fetal growth velocity had good prediction of placental MVM lesions, as an indicator of fetal growth restriction irrespective of neonatal weight.
Databáze: OpenAIRE
Externí odkaz: