The metabolic and neuroinflammatory changes induced by consuming a cafeteria diet are age-dependent
| Autor: | Luciano Fraga, Maria Flavia Marques Ribeiro, Wania Aparecida Partata, Deborah S. Teixeira, Ana Lúcia Cecconello, Renata Padilha Guedes |
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| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Leptin 0301 basic medicine Aging medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) tau Proteins Cafeteria Diet High-Fat Hippocampus 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Animals Insulin Medicine Hippocampus (mythology) Rats Wistar Cerebral Cortex Nutrition and Dietetics biology business.industry General Neuroscience Brain General Medicine medicine.disease biology.organism_classification Obesity 030104 developmental biology medicine.anatomical_structure Endocrinology Cerebral cortex Encephalitis Female Insulin Resistance medicine.symptom business Neuroglia Weight gain 030217 neurology & neurosurgery |
| Zdroj: | Nutritional Neuroscience. 22:284-294 |
| ISSN: | 1476-8305 1028-415X |
| DOI: | 10.1080/1028415x.2017.1380892 |
| Popis: | To compare the effects of a palatable cafeteria diet on serum parameters and neuroinflammatory markers of young and aged female Wistar rats.Three-month-old (young) and 18-month-old (aged) female Wistar rats had access to a cafeteria diet (Caf-Young, Caf-Aged) or a standard chow diet (Std-Young, Std-Aged).The Caf-Young group showed a higher food consumption, weight gain, visceral fat depot, serum insulin and leptin levels, and the insulin resistance index (HOMA-IR) than the Std-Young group. The Caf-Aged group exhibited an increase in interleukin-1 levels in the cerebral cortex and hippocampus. The number of GFAP-positive cells did not differ between the groups, but there was a diet effect in the cerebral cortex and an age effect in the hippocampus. Phospho-tau expression did not differ between the groups.The 3- and 18-month-old rats responded differently to a cafeteria diet. Insulin and leptin levels are elevated in young animals fed a cafeteria diet, whereas aged animals are prone to neuroinflammation (indicated by an increase in interleukin-1β levels). A combination of hypercaloric diet and senescence have detrimental effects on the inflammatory response in the brain, which may predispose to neurological diseases. |
| Databáze: | OpenAIRE |
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