Analysis of interobserver reproducibility in grading dysplastic nevi: Results of the application of the 2018 World Health Organization grading criteria

Autor: Cuyan Demirkesen, Pelin Yildiz, Hazal Cansu Acar, Ovgu Aydin Ulgen
Přispěvatelé: YILDIZ, PELİN
Rok vydání: 2021
Předmět:
Zdroj: Journal of Cutaneous Pathology. 49:343-349
ISSN: 1600-0560
0303-6987
DOI: 10.1111/cup.14165
Popis: Background We aimed to determine whether the histopathological grading of dysplastic nevi is an objective endeavour, considering interobserver variability, according to 2018 World Health Organization (WHO) Criteria. Methods In total, 179 cases of dysplastic nevi, with high and moderate degree of atypia, diagnosed and graded according to the previous criteria were reviewed by three pathologists. Then the observers graded the dysplastic nevi as low or high according to 2018 WHO criteria. Results Grading of dysplastic nevi was in complete agreement in 99 of 179 cases across three observers with a fair level of overall interobserver agreement (multirater Kfree: 0.40). The observers showed moderate to good agreement for most of the architectural features, except for criteria regarding focal continuous basal proliferation of melanocytes, density of non- nested junctional melanocytes and presence of dyscohesive nests of intraepidermal melanocytes. Whereas fair agreement was achieved for the cytological criteria. Conclusions The 2018 WHO criteria for dysplastic nevus will ensure a common approach to diagnosis and grading of dysplastic nevi. However, histopathological criteria, such as cytological features and focal continuous basal proliferation of melanocytes, should be improved, so as to ensure a more accurate surgical approach and risk assessment. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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