MYASTHENIA GRAVIS AND POLYMYOSITIS IN A DOG FOLLOWING FETAL HEMATOPOIETIC CELL TRANSPLANTATION
| Autor: | G. R. Cain, George H. Cardinet, Richard E. Champlin, Paul A. Cuddon, Robert Peter Gale |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Neuromuscular Junction Polymyositis Antibodies Autoimmune Diseases chemistry.chemical_compound Dogs Fetus Transplantation Immunology Myasthenia Gravis medicine Animals Transplantation Homologous Autoimmune disease Transplantation Myositis business.industry Muscles Vaccination Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells medicine.disease Acetylcholinesterase Muscle atrophy Myasthenia gravis Liver Pyridostigmine chemistry Radiation Chimera Immunology Prednisolone Female medicine.symptom business medicine.drug |
| Zdroj: | Transplantation. 41:21-25 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-198601000-00003 |
| Popis: | Myasthenia gravis and focal polymyositis occurred in a dog following successful transplantation of DLA-identical fetal liver hematopoietic cells. There was no evidence of acute or chronic graft-versus-host disease. Antibodies to acetylcholinesterase receptor and immune complexes reactive with myoneural junctions were demonstrated, as well as focal inflammation with perifascicular and type 2 muscle atrophy. The dog responded to treatment with prednisolone and pyridostigmine. |
| Databáze: | OpenAIRE |
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