MANAGEMENT OF OSTEOARTHRITIS IN A GIANT PANDA (AILUROPODA MELANOLEUCA) WITH MULTIMODAL THERAPY INCLUDING AMANTADINE SULPHATE
| Autor: | Lee Foo Khong, Elke Wu, Paolo Martelli, Nimal Fernando, Cissy Kou, Kathy Larson |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
040301 veterinary sciences
Carbazoles Osteoarthritis Amantadine sulphate 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glucosamine biology.animal medicine Amantadine Animals Carprofen Ailuropoda melanoleuca 030222 orthopedics General Veterinary biology business.industry Anti-Inflammatory Agents Non-Steroidal Multimodal therapy 04 agricultural and veterinary sciences General Medicine Analgesics Non-Narcotic medicine.disease chemistry Lameness Anesthesia Animal Science and Zoology Animals Zoo Female business Ursidae medicine.drug |
| Zdroj: | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 47(1) |
| ISSN: | 1042-7260 |
| Popis: | In 2002 a 23-yr-old female giant panda (Ailuropoda melanoleuca) presented with left hind limb lameness presumably due to osteoarthritis. For the next five years, arthritic episodes were managed with the nonsteroidal anti-inflammatory drug (NSAID) carprofen at 2 mg/kg p.o. s.i.d., then reduced to 1 mg/kg p.o. s.i.d. and withdrawn. Radiographs revealed osteoarthritis in various joints and lumbar spondylosis. In 2007 glucosamine and chondroitin at 1.65 g p.o. b.i.d. and a polyunsaturated fatty acid at 1 capsule p.o. s.i.d. By 2008, arthritic episodes were becoming more difficult to successfully manage and higher doses and longer durations of treatment with carprofen were needed (2 mg/kg p.o. b.i.d.) and by August 2009 episodic treatment was no longer successful so the carprofen was continued indefinitely at 1 mg/kg p.o. s.i.d. In November 2009 carprofen was increased to 2 mg/kg p.o. b.i.d. An NMDA antagonist amantadine sulphate was trialed and after 10 days at 200 mg p.o. s.i.d. the clinical signs resolved. Since then it has been maintained on carprofen at 1 mg/kg p.o. b.i.d., amantadine sulphate 200 mg p.o. s.i.d. and the neutraceuticals as above with no further relapses of arthritic pain. |
| Databáze: | OpenAIRE |
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