Morphological abnormalities in nitric-oxide-synthase-positive striatal interneurons of schizophrenic patients
| Autor: | Silvia Johannes, S. Fritzen, Martin Lauer, Peter Riederer, Dieter Senitz, Andreas Reif |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Psychosis Interneuron Nitric Oxide Synthase Type II Cell Count Biology behavioral disciplines and activities Neurodevelopmental disorder Interneurons mental disorders Basal ganglia medicine Humans Coloring Agents Biological Psychiatry Aged Aged 80 and over Putamen NADPH Dehydrogenase Middle Aged medicine.disease Immunohistochemistry Nitric oxide synthase Neostriatum Psychiatry and Mental health B vitamins Neuropsychology and Physiological Psychology medicine.anatomical_structure Schizophrenia biology.protein Female Nitric Oxide Synthase Neuroscience |
| Zdroj: | Neuropsychobiology. 52(3) |
| ISSN: | 0302-282X |
| Popis: | Schizophrenia has been suggested to be a neurodevelopmental disorder, and nitric-oxide-synthase (NOS)-positive neurons were shown to be involved in distorted cortical development in schizophrenia. Here we investigated whether nitrinergic neurons in the striatum of schizophrenic patients also display abnormalities regarding distribution or morphology. To do so, postmortem putaminal sections of schizophrenic subjects were examined by means of nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd) staining and NOS immunohistochemistry. NOS-positive neurons were counted and analyzed morphologically. Abnormalities regarding morphology or number of NOS-containing neurons could be found in the putamen of schizophrenics (n = 3), but not controls (n = 5). Neurons were either of abnormal size and branching pattern, or they were markedly reduced (130 ± 44 vs. 54 ± 62 NADPHd-positive somata/mm3 putamen; p < 0.0001). Striatal nitrinergic interneurons might thus be involved in the pathogenesis of at least some forms of schizophrenia. Studies on larger samples are however needed to further corroborate this finding. |
| Databáze: | OpenAIRE |
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