A G4·K(+) hydrogel that self-destructs
| Autor: | Jeffery T. Davis, Taylor N. Plank |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Stereochemistry
Chemistry Metals and Alloys Intramolecular cyclization Molecular Conformation 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Catalysis Molecular conformation Hydrogel Polyethylene Glycol Dimethacrylate 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Cyclization Materials Chemistry Ceramics and Composites 0210 nano-technology |
| Zdroj: | Chemical communications (Cambridge, England). 52(28) |
| ISSN: | 1364-548X |
| Popis: | A G4-quartet based hydrogel formed by self-assembly of borate esters of 5′-deoxy-5′-iodoguanosine (5′-IG 2) undergoes in situ cyclization to give 5′-deoxy-N3,5′-cycloguanosine (5′-cG 3). Formation of 5′-cG 3 causes self-destruction of the gel. This intramolecular cyclization can be used to release nucleoside analogs that have been pre-incorporated into the gel network. |
| Databáze: | OpenAIRE |
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