A Deferasirox Derivative That Acts as a Multifaceted Platform for the Detection and Quantification of Fe3+
| Autor: | Yu-Ying Wang, Michael Y. Zhao, Adam C. Sedgwick, Axel Steinbrueck, Suh-Mi Hwang, Dan-Ying Huang, Jonathan L. Sessler, Sajal Sen, Daniel M. Knoll |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
water samples
02 engineering and technology 010402 general chemistry 01 natural sciences Analytical Chemistry Metal lcsh:Biochemistry chemistry.chemical_compound medicine Chelation lcsh:QD415-436 Physical and Theoretical Chemistry Iron Chelator iron chelation Aqueous solution chemosensor Deferasirox 021001 nanoscience & nanotechnology Human serum albumin Fluorescence 0104 chemical sciences chemistry visual_art visual_art.visual_art_medium 0210 nano-technology Derivative (chemistry) deferasirox Nuclear chemistry medicine.drug |
| Zdroj: | Chemosensors Volume 9 Issue 4 Chemosensors, Vol 9, Iss 68, p 68 (2021) |
| ISSN: | 2227-9040 |
| DOI: | 10.3390/chemosensors9040068 |
| Popis: | Here, we report that ExSO3H, a synthetically accessible, water-soluble, non-toxic derivative of the clinical iron chelator deferasirox, acts as a colorimetric chemosensor that permits the detection and quantification of Fe3+ in aqueous samples at pH 2–5. In addition, we observed that a fluorescent turn-on response was produced when this chelator was allowed to interact with human serum albumin (HSA). This fluorescence was quenched in the presence of Fe3+, thus allowing us to monitor the presence of this biologically important metal cation via two independent methods. |
| Databáze: | OpenAIRE |
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