Risk Factors for Postoperative Prolonged Mechanical Ventilation After Pediatric Liver Transplantation
| Autor: | Adnan Torgay, Helin Sahinturk, Aycan Ozdemirkan, Arash Pirat, Mehmet Haberal, Pinar Zeyneloglu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_treatment Liver transplantation law.invention law Risk Factors medicine Humans Child Hepatic encephalopathy Retrospective Studies Mechanical ventilation Transplantation Aspartic Acid business.industry Incidence (epidemiology) Odds ratio Length of Stay medicine.disease Intensive care unit Respiration Artificial Confidence interval Liver Transplantation Treatment Outcome Anesthesia Hepatic Encephalopathy Female Packed red blood cells business |
| Zdroj: | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 19(9) |
| ISSN: | 2146-8427 |
| Popis: | Objectives Duration of postoperative mechanical ventilation after pediatric liver transplant may influence pulmonary functions, and postoperative prolonged mechanical ventilation is associated with higher morbidity and mortality. Here, we determined its incidence and risk factors after pediatric liver transplant at our center. Materials and methods We retrospectively analyzed the records of 121 children who underwent liver transplant between April 2007 and April 2017 (305 total liver transplant procedures were performed during this period). Prolonged mechanical ventilation was defined as postoperative tracheal extubation after 24 hours. Results Mean age at transplant was 6.2 ± 5.4 years and 71/121 children (58.7%) were male. Immediate tracheal extubation was achieved in 68 children (56.2%). Postoperative prolonged mechanical ventilation was needed in 12 children (9.9%), with mean extubation time of 78.0 ± 83.4 hours. Reintubation was required in 13.4%. Logistic regression analysis revealed that presence of preoperative hepatic encephalopathy (odds ratio of 0.130; 95% confidence interval, 0.027-0.615; P = .01), high aspartate amino transferase levels (odds ratio of 1.001; 95% confidence interval, 1.000-1.002; P = .02), intraoperative usage of more packed red blood cells (odds ratio of 1.001; 95% confidence interval, 1.000-1.002; P = .04), and longer surgery duration (odds ratio of 0.723; 95% confidence interval, 0.555-0.940, P = .01) were independent risk factors for postoperative prolonged mechanical venti-lation. Although mean length of intensive care unit stay was significantly longer (12.6 ± 13.6 vs 6.0 ± 0.6 days; P = .001), mortality was similar in children with and without postoperative prolonged mechanical ventilation. Conclusions Our results indicate that postoperative prolonged mechanical ventilation was needed in 9.9% of our children. Predictors of postoperative prolonged mechanical ventilation after pediatric liver transplant at our center were preoperative presence of hepatic encephalopathy, high aspartate amino transferase levels, intraoperative usage of more packed red blood cells, and longer surgery duration. |
| Databáze: | OpenAIRE |
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