MicroRNA-192 suppresses cell proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes by downregulating caveolin 1
| Autor: | Zhenmu Jin, Xiaobing Lu, Supin Li |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Cell cycle checkpoint Clinical Biochemistry Caveolin 1 Down-Regulation Apoptosis Biology Arthritis Rheumatoid 03 medical and health sciences microRNA medicine Gene silencing Humans Fibroblast Molecular Biology Cells Cultured Aged Cell Proliferation Cell growth Cell Biology General Medicine Fibroblasts Middle Aged Molecular biology Synoviocytes MicroRNAs 030104 developmental biology medicine.anatomical_structure Ectopic expression Female |
| Zdroj: | Molecular and cellular biochemistry. 432(1-2) |
| ISSN: | 1573-4919 |
| Popis: | Fibroblast-like synoviocytes (FLSs) play an important role in the pathogenesis of rheumatoid arthritis (RA). This study was conducted to explore the role of microRNA (miR)-192 in the regulation of the biology of RA-FLSs. The expression of miR-192 in RA and healthy synovial tissues was measured. The effects of overexpression of miR-192 on RA-FLS proliferation and apoptosis were investigated. Luciferase reporter assay and Western blot analysis were performed to identify direct target genes of miR-192. RA synovial tissues had significantly lower levels of miR-192 than healthy controls (P = 0.004). Moreover, miR-192 levels were 2.9-fold lower in RA-FLSs relative to normal human FLSs (P |
| Databáze: | OpenAIRE |
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