Cannabidiol reduces lung injury induced by hypoxic-ischemic brain damage in newborn piglets
| Autor: | Luis Arruza, Nagat Mohammed, Natalia Escribano, Hector Lafuente, William H Hind, María Ruth Pazos, Francisco J. Alvarez-Diaz, Martín Santos, José Martínez-Orgado |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Swine Interleukin-1beta Inflammation Brain damage Pulmonary compliance Lung injury medicine.disease_cause 03 medical and health sciences 0302 clinical medicine medicine Animals Cannabidiol Hypoxia Lung medicine.diagnostic_test business.industry Hemodynamics Brain Lung Injury respiratory system digestive system diseases respiratory tract diseases Oxygen Disease Models Animal Oxidative Stress 030104 developmental biology medicine.anatomical_structure Bronchoalveolar lavage Animals Newborn Anesthesia Pediatrics Perinatology and Child Health Hypoxia-Ischemia Brain medicine.symptom business Bronchoalveolar Lavage Fluid 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Pediatric research. 82(1) |
| ISSN: | 1530-0447 |
| Popis: | Brain hypoxic–ischemic (HI) damage induces distant inflammatory lung damage in newborn pigs. We aimed to investigate the effects of cannabidiol (CBD) on lung damage in this scenario. Newborn piglets received intravenous vehicle, CBD, or CBD+WAY100635 (5-HT1A receptor antagonist) after HI brain damage (carotid flow interruption and FiO2 0.10 for 30 min). Total lung compliance (TLC), oxygenation index (OI), and extravascular lung water content (EVLW) were monitored for 6 h. Histological damage, interleukin (IL)-1β concentration, and oxidative stress were assessed in brain and lung tissue. Total protein content was determined in bronchoalveolar lavage fluid (BALF). CBD prevented HI-induced deleterious effects on TLC and OI and reduced lung histological damage, modulating inflammation (decreased leukocyte infiltration and IL-1 concentration) and reducing protein content in BALF and EVLW. These effects were related to CBD-induced anti-inflammatory changes in the brain. HI did not increase oxidative stress in the lungs. In the lungs, WAY100635 blunted the beneficial effects of CBD on histological damage, IL-1 concentration, and EVLW. CBD reduced brain HI-induced distant lung damage, with 5-HT1A receptor involvement in these effects. Whether the effects of CBD on the lungs were due to the anti-inflammatory effects on the brain or due to the direct effects on the lungs remains to be elucidated. |
| Databáze: | OpenAIRE |
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