Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain
| Autor: | Kindt Tj, Alling Dw, Thomas Ml, Hampshire Va, Bacher Jd, Simpson Rm, Wyatt Rg |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Ketoprofen medicine.medical_specialty Biopsy medicine.medical_treatment Analgesic Lung biopsy Animal Welfare Chest pain Dinoprostone Norepinephrine chemistry.chemical_compound Corticosterone Bronchoscopy Thoracoscopy Animals Medicine Thoracotomy Lung Pain Postoperative Behavior Animal medicine.diagnostic_test business.industry Anti-Inflammatory Agents Non-Steroidal Limiting Specific Pathogen-Free Organisms Surgery Disease Models Animal chemistry Anesthesia Female Rabbits Blood Gas Analysis medicine.symptom Anesthesia Inhalation business medicine.drug |
| Zdroj: | Journal of Investigative Surgery. 14:109-120 |
| ISSN: | 1521-0553 0894-1939 |
| DOI: | 10.1080/08941930152024237 |
| Popis: | Diminished tissue injury and shortened clinical recovery are benefits of using an endoscopic approach for patients needing operative procedure. In the course of developing an experimental model requiring procurement of topographically precise lung biopsy specimens, we sought to apply thoracoscopy as a research alternative to thoracotomy. In addition, we investigated the influence of thoracoscopy on postprocedure recovery practices using rabbits divided into four treatment groups. Rabbit groups 1 and 2 underwent thoracoscopy and lung biopsy while maintained by one-lung anesthesia. Additionally, group 2 had ketoprofen and bupivacaine HCl analgesics injected for treatment during postprocedure recovery. These two groups were compared to control rabbits in groups 3 and 4, which underwent inhalant anesthesia without thoracoscopy. Control group 3 also received the injection analgesic combination. During recovery, rabbit behavior was systematically assessed for evidence of pain. No behavior considered indicative of pain needing intervention was observed regardless of treatment group. Limited changes in plasma corticosterone, catecholamines, and prostaglandin E2 levels measured during recovery were difficult to associate with any treatment. Unexpectedly, significantly different mean corticosterone and catecholamines levels were detected in rabbits given the injection analgesic combination in the absence of thoracoscopic procedure, as compared to other treatment groups. The results highlight the importance of awareness that analgesic drug administration has the potential to alter homeostasis and affect interpretation of some study findings by its own guise. Correlation of the mean pain study results with plasma biochemical data supports preferential use of thoracoscopy as a refinement for limiting postprocedural pain in research models. |
| Databáze: | OpenAIRE |
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