Allogreffe de cellules souches hématopoïétiques dans la drépanocytose de l’enfant et de l’adulte : indications et modalités
| Autor: | Emmanuelle Bernit, Yves Beguin, Stavroula Masouridi-Levrat, Ibrahim Yakoub-Agha, Catherine Paillard, Marie Ouachee, Corinne Pondarré, Jean-Hugues Dalle, Nathalie Dhedin, Eolia Brissot, Nimrod Buchbinder |
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| Přispěvatelé: | CCSD, Accord Elsevier, Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Strasbourg, Hôpital Robert Debré, Université Paris Diderot - Paris 7 (UPD7), Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL] (IHOPe), Hospices Civils de Lyon (HCL), Service de pédiatrie médicale et médecine de l'adolescent [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service d'hématologie clinique et de thérapie cellulaire [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université de Liège, Centre Hospitalier Universitaire de Liège (CHU-Liège), Hôpitaux Universitaires de Genève (HUG), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Assistance Publique - Hôpitaux de Marseille (APHM), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Hospitalier Intercommunal de Créteil (CHIC), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Pediatrics medicine.medical_specialty Conditionnement medicine.medical_treatment Drépanocytose [SDV]Life Sciences [q-bio] Hydroxycarbamide 03 medical and health sciences 0302 clinical medicine Conditioning regimen medicine Radiology Nuclear Medicine and imaging Allogreffe de cellules souches hématopoïétiques business.industry Sickle cell disease Hematopoietic stem cell Immunosuppression Hematology General Medicine Total body irradiation 3. Good health [SDV] Life Sciences [q-bio] Regimen 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Allogeneic hematopoietic stem cell transplantation Alemtuzumab Stem cell Indications business Busulfan medicine.drug |
| Zdroj: | Bulletin du Cancer Bulletin du Cancer, 2020, 107, pp.925-933. ⟨10.1016/j.bulcan.2020.06.003⟩ Bulletin du Cancer, John Libbey Eurotext, 2020, 107, pp.925-933. ⟨10.1016/j.bulcan.2020.06.003⟩ |
| ISSN: | 0007-4551 1769-6917 |
| Popis: | International audience; Sickle cell disease is associated with severe complications and early mortality in adults. In children, hematopoietic stem cell transplant from HLA-identical sibling can stop the progression of the disease and leads to more than 95% long-term free survival without sickle cell disease. The aim of this workshop was to define indications and modalities of allogeneic hematopoietic stem cell transplant in children and adults with sickle cell disease. Patient and sibling HLA typing should be proposed, early in the course of the disease, when intensification therapies are required. Indications of transplant from HLA-identical sibling in children and adults are, cerebral vasculopathy, occurrence of vaso-occlusive events despite hydroxycarbamide, renal and hepatic diseases related to SCD, chronic anemia |
| Databáze: | OpenAIRE |
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