Forced Running Endurance Is Influenced by Gene(s) on Mouse Chromosome 10
| Autor: | Arimantas Lionikas, Mindaugas Kvedaras, Petras Minderis, Andrej Fokin, Tomas Venckunas, Aivaras Ratkevicius |
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| Přispěvatelé: | Frontiers media SA |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology specific force Consomic Strain Biology Contractility 03 medical and health sciences Endurance training Physiology (medical) Internal medicine medicine skeletal muscle electric stimulation chromosome substitution strains Original Research Specific force Strain (chemistry) exercise Laboratory mouse Skeletal muscle Chromosome Anatomy 030104 developmental biology medicine.anatomical_structure Endocrinology |
| Zdroj: | Frontiers in Physiology |
| ISSN: | 1664-042X |
| DOI: | 10.3389/fphys.2017.00009 |
| Popis: | Phenotypic diversity between laboratory mouse strains provides a model for studying the underlying genetic mechanisms. The A/J strain performs poorly in various endurance exercise models. The aim of the study was to test if endurance capacity and contractility of the fast- and slow-twitch muscles are affected by the genes on mouse chromosome 10. The C57BU6J (B6) strain and C57BU6J-Chr 10(A/J)/NaJ (B6.A10) consomic strain which carries the A/J chromosome 10 on a B6 strain background were compared. The B6.A10 mice compared to B6 were larger in body weight (p < 0.02): 27.2 +/- 1.9 vs. 23.8 +/- 2.7 and 23.4 +/- 1.9 vs. 22.9 +/- 2.3 g, for males and females, respectively, and in male soleus weight (p < 0.02): 9.7 +/- 0.4 vs. 8.6 +/- 0.9 mg. In the forced running test the B6.A10 mice completed only 64% of the B6 covered distance (p < 0.0001). However, there was no difference in voluntary wheel running (p = 0.6) or in fatigability of isolated soleus (p = 0.24) or extensor digitorum longus (EDL, p = 0.7) muscles. We conclude that chromosome 10 of the A/J strain contributes to reduced endurance performance. We also discuss physiological mechanisms and methodological aspects relevant to interpretation of these findings. |
| Databáze: | OpenAIRE |
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