Effect of Plasmodium falciparum Parasitemia on Erythrocyte Zinc Protoporphyrin
| Autor: | Abhai K. Tripathi, Robert E. Black, Girish Hiremath, Sunil Sazawal, David J. Sullivan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Erythrocytes
business.industry Holoendemic Plasmodium falciparum Biochemistry (medical) Clinical Biochemistry Zinc protoporphyrin Protoporphyrins Transferrin receptor Parasitemia Iron deficiency medicine.disease Hemolysis chemistry.chemical_compound chemistry parasitic diseases Immunology medicine Animals Humans business Malaria Anemia of chronic disease |
| Zdroj: | Clinical Chemistry. 52:778-779 |
| ISSN: | 1530-8561 0009-9147 |
| Popis: | In regions holoendemic for malaria, both iron deficiency and asymptomatic malaria parasitemia are common (1). Measurements of transferrin receptor and erythrocyte zinc protoporphyrin IX (ZnPPIX) concentrations have been suggested as screening tools to detect iron deficiency (1)(2). Chronic iron-deficient erythropoiesis leads to a relative increase in the insertion of zinc rather than iron into erythrocyte PPIX. Anemia of chronic disease and hyperbilirubinemia can decrease the specificity of an iron deficiency diagnosis based on hematofluorometry-determined increases in the ratio of ZnPPIX to heme. The influence of malaria parasitemia on front-face hematofluorometric ZnPPIX determinations is controversial. Increased ZnPPIX has been statistically associated with malaria, and interference by increased bilirubin from hemolysis has been postulated (3). In a study by Asobayire et al.(4), malaria did not increase ZnPPIX in washed blood, but in that study only 5%–8% of malaria-positive persons had >5000 … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|