Pharmacological evidence for inhibition of ACTH secretion by a central adrenergic system in the dog
| Autor: | Norman Kramer, Robert Lovinger, Roy Shackelford, Umberto Scapagnini, A. T. Boryczka, Jane E. Salmon, William F. Ganong, Ian A. Reid |
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| Rok vydání: | 1976 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Phenoxybenzamine Biology Receptors Dopamine Norepinephrine Phentolamine Catecholamines Dogs Adrenocorticotropic Hormone Dopamine Stress Physiological Internal medicine Receptors Adrenergic beta medicine Animals ACTH receptor Catecholaminergic General Neuroscience Brain Neural Inhibition Receptors Adrenergic alpha Apomorphine Endocrinology Epinephrine hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Neuroscience. 1(3) |
| ISSN: | 0306-4522 |
| Popis: | To obtain more information about the transmitter involved in catecholaminergic inhibition of ACTH secretion, the site of this inhibition, and the receptors involved, the secretion of ACTH was studied in pentobarbital-anesthetized dogs that were surgically stressed and treated with drugs which modify central catecholaminergic transmission. The index of ACTH secretion was adrenal venous output of corticoid hormones. Intravenous L-dopa inhibited ACTH secretion, and this inhibition was not modified by blockade of peripheral decarboxylation of L-dopa with carbidopa. Intravenous or centrally administered clonidine inhibited stress-induced ACTH secretion, whereas centrally administered apomorphine did not. When given into the third ventricle, phenoxybenzamine (but not phentolamine) blocked the inhibitory effect of L-dopa and clonidine. Pimozide had no effect. L-propranolol caused a small but significant decrease in stress-induced ACTH secretion. Intraventricular procaine blocked the stress response. The data support the conclusion that the site of catecholaminergic inhibition of ACTH secretion is central, 'inside the blood-brain barrier', instead of the pituitary or the median eminence. They indicate that dopamine is not the mediator involved, and suggest that it is probably norepinephrine, although epinephrine is not ruled out. The receptor on which the released catecholamines act, presumably on the surface of the cells that secrete the hypothalamic hormone that regulates ACTH secretion, appears to be a type of alpha-adrenergic receptor. |
| Databáze: | OpenAIRE |
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