| Autor: |
P Distefano, Stefano Iacobelli, Nicola Tinari, R. Tenaglia, Clara Natoli, Bruno Fiorentino, Domenico Angelucci, C. Amatetti |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
International journal of oncology. 3(5) |
| ISSN: |
1019-6439 |
| Popis: |
We have investigated whether the expression of Epidermal Growth Factor Receptors (EGF-Rc) evaluated by immunohistochemical technique, may influence the prognosis of patients with prostate cancer. EGF-Rc were positive in 20/76 (26.3%) of tumors. There was no correlation between EGF-Rc and other prognostic factors such as tumor size, Gleason score, metastases at diagnosis, DNA content and S-Phase fraction (SPF). In patients with locally advanced tumors EGF-Rc expression was significantly correlated with the presence of metastases at diagnosis (p=0.038). Both disease-free survival (DFS) and overall survival (OS) did not differ between patients with receptor-positive and receptor-negative tumors. It is concluded that the immunohistochemical localization of EGF-Rc is of limited prognostic value in prostate cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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