Effects of chronic infusion of nerve growth factor (NGF) in AF64A-lesioned rats
| Autor: | Odalys González, Johanka Soto, Lazaro Alvarez, Zenaida Quijano, Caridad Ivette Fernández |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Aziridines Morris water navigation task Hippocampus Choline Choline O-Acetyltransferase Lesion Rats Sprague-Dawley Cognition Internal medicine medicine Avoidance Learning Animals Nerve Growth Factors Cholinergic neuron Infusions Intravenous Maze Learning Molecular Biology Cerebral Cortex business.industry General Neuroscience Brain medicine.disease Choline acetyltransferase Corpus Striatum Rats Sprague dawley Nerve growth factor Endocrinology nervous system Neurology (clinical) medicine.symptom Alzheimer's disease Passive avoidance Neuromuscular Blocking Agents business Cognition Disorders Neuroscience |
| Zdroj: | Molecular and chemical neuropathology. 28(1-3) |
| ISSN: | 1044-7393 |
| Popis: | We report here the behavioral and biochemical recovery induced by the nerve growth factor (NGF) administration in AF64A-treated rats. Retention in the passive avoidance test was affected by lesion but it was significantly improved after the NGF treatment. Similar results were observed in the performance during the Morris water maze (MWM) task. Remarkable losses in the ChAT activity were detected in some brain regions from lesioned rats. The NGF-induced alleviation of choline acetyltransferase (ChAT) activity losses and cognitive functions suggest a trophic and protective action on the remaining cholinergic neurons after the lesion. Thus NGF therapy could be considered as a possibility mainly in the early course of Alzheimer disease. |
| Databáze: | OpenAIRE |
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