The mechanism of action of aflatoxin B1; observations on virus-infected cells
| Autor: | Laura E. Crook, K. R. Rees, E.H. Harley, A. Cohen |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Electrophoresis
Aflatoxin Time Factors DNA polymerase Vaccinia virus Tritium Toxicology Ribosome Virus HeLa chemistry.chemical_compound Aflatoxins Polysome Thymine Nucleotides heterocyclic compounds RNA Messenger Uridine biology food and beverages RNA DNA General Medicine biology.organism_classification Molecular biology Kinetics Poliovirus chemistry Biochemistry Isotope Labeling DNA Nucleotidyltransferases DNA Viral biology.protein RNA Viral HeLa Cells Thymidine |
| Zdroj: | Chemico-Biological Interactions. 5:107-116 |
| ISSN: | 0009-2797 |
| DOI: | 10.1016/0009-2797(72)90037-3 |
| Popis: | 1. (1)|Aflatoxin B 1 inhibits viral DNA-directed DNA, DNA-directed RNA and RNA-directed RNA synthesis. 2. (2)|In aflatoxin B 1 -treated HeLa cells, in which cellular protein synthesis is inhibited, synthesis of vaccinia DNA polymerase is unaffected. This indicates that the ribosomes derived from polysome disaggregation by aflatoxin B 1 retain their functional capacity. |
| Databáze: | OpenAIRE |
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