Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes
| Autor: | Andrew K. Recknagel, Ewan C. McNay |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cognitive Neuroscience
medicine.medical_treatment Hippocampus Experimental and Cognitive Psychology Type 2 diabetes Hippocampal formation Article Behavioral Neuroscience Insulin resistance Diabetes mellitus medicine Animals Humans Insulin biology Brain Cognition medicine.disease Rats Insulin receptor Diabetes Mellitus Type 2 biology.protein Insulin Resistance Psychology Cognition Disorders Neuroscience |
| Zdroj: | Neurobiology of learning and memory. 96(3) |
| ISSN: | 1095-9564 |
| Popis: | Understanding of the role of insulin in the brain has gradually expanded, from initial conceptions of the brain as insulin-insensitive through identification of a role in regulation of feeding, to recent demonstration of insulin as a key component of hippocampal memory processes. Conversely, systemic insulin resistance such as that seen in type 2 diabetes is associated with a range of cognitive and neural deficits. Here we review the evidence for insulin as a cognitive and neural modulator, including potential effector mechanisms, and examine the impact that type 2 diabetes has on these mechanisms in order to identify likely bases for the cognitive impairments seen in type 2 diabetic patients. |
| Databáze: | OpenAIRE |
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