Efficient Synthesis of N-Alkyl Tetrahydroisoquinolines by Reductive Amination

Autor:	Hephzibah J. Kumpaty, Sukanta Bhattacharyya
Rok vydání:	2005
Předmět:	chemistry.chemical_classification Chemistry Tetrahydroisoquinoline Organic Chemistry General Medicine Sulfonic acid Reductive amination Catalysis chemistry.chemical_compound THIQ medicine Organic chemistry Alkyl medicine.drug
Zdroj:	Synthesis. 2005:2205-2209
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-2005-872081
Popis:	An expedient access to diverse N-alkyl 1,2,3,4-tetrahydroisoquinolines is reported by reductive amination of aldehydes and ketones with tetrahydroisoquinoline (THIQ) in the presence of Ti(Oi-Pr) 4 and NaBH 4 . The N-alkyl THIQ products were rapidly purified by flow-through catch and release technique using commercially available polymer-supported sulfonic acid, MP-TsOH columns.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ad4abbf97e1613fa9cbbc874d6071b https://doi.org/10.1055/s-2005-872081 Zobrazit plný text záznamu