Modelling second malignancy risks from low dose rate and high dose rate brachytherapy as monotherapy for localised prostate cancer
| Autor: | Peter Hoskin, Louise Murray, Jack L.M. Venselaar, Joshua Mason, Ann Henry, Frank-André Siebert, Peter Bownes |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Male Neoplasms Radiation-Induced medicine.medical_treatment Brachytherapy Tomography X-Ray Computed/methods 030218 nuclear medicine & medical imaging Prostate cancer 0302 clinical medicine Prostate Urinary bladder Manchester Cancer Research Centre Neoplasms Second Primary Radiotherapy Dosage Hematology High-Dose Rate Brachytherapy Low-Dose Rate Brachytherapy Neoplasms Radiation-Induced/etiology medicine.anatomical_structure 030220 oncology & carcinogenesis Prostatic Neoplasms/diagnostic imaging Radiology Rectum/radiation effects Risk medicine.medical_specialty Urinary Bladder Brachytherapy/adverse effects Models Biological 03 medical and health sciences Internal medicine medicine Humans Radiology Nuclear Medicine and imaging External beam radiotherapy Urinary Bladder Neoplasms/etiology Bladder cancer business.industry Rectal Neoplasms Urinary Bladder/radiation effects ResearchInstitutes_Networks_Beacons/mcrc Rectal Neoplasms/etiology Rectum Prostatic Neoplasms Dose-Response Relationship Radiation medicine.disease Neoplasms Second Primary/etiology Urinary Bladder Neoplasms business Tomography X-Ray Computed |
| Zdroj: | UroGEC/BRAPHYQS group of the GEC ESTRO 2016, ' Modelling second malignancy risks from low dose rate and high dose rate brachytherapy as monotherapy for localised prostate cancer ', Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 120, no. 2, pp. 293-9 . https://doi.org/10.1016/j.radonc.2016.05.026 |
| ISSN: | 1879-0887 |
| Popis: | BACKGROUND AND PURPOSE: To estimate the risks of radiation-induced rectal and bladder cancers following low dose rate (LDR) and high dose rate (HDR) brachytherapy as monotherapy for localised prostate cancer and compare to external beam radiotherapy techniques.MATERIALS AND METHODS: LDR and HDR brachytherapy monotherapy plans were generated for three prostate CT datasets. Second cancer risks were assessed using Schneider's concept of organ equivalent dose. LDR risks were assessed according to a mechanistic model and a bell-shaped model. HDR risks were assessed according to a bell-shaped model. Relative risks and excess absolute risks were estimated and compared to external beam techniques.RESULTS: Excess absolute risks of second rectal or bladder cancer were low for both LDR (irrespective of the model used for calculation) and HDR techniques. Average excess absolute risks of rectal cancer for LDR brachytherapy according to the mechanistic model were 0.71 per 10,000 person-years (PY) and 0.84 per 10,000 PY respectively, and according to the bell-shaped model, were 0.47 and 0.78 per 10,000 PY respectively. For HDR, the average excess absolute risks for second rectal and bladder cancers were 0.74 and 1.62 per 10,000 PY respectively. The absolute differences between techniques were very low and clinically irrelevant. Compared to external beam prostate radiotherapy techniques, LDR and HDR brachytherapy resulted in the lowest risks of second rectal and bladder cancer.CONCLUSIONS: This study shows both LDR and HDR brachytherapy monotherapy result in low estimated risks of radiation-induced rectal and bladder cancer. LDR resulted in lower bladder cancer risks than HDR, and lower or similar risks of rectal cancer. In absolute terms these differences between techniques were very small. Compared to external beam techniques, second rectal and bladder cancer risks were lowest for brachytherapy. |
| Databáze: | OpenAIRE |
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