Mycobacterium microti: not just a coincidental pathogen for cats
| Autor: | Patricia Landolt, Mirjam Senn, Anja Kipar, Giovanni Ghielmetti, Roger Stephan, Sandro Hinden, Matthias Dennler, Sophie Peterhans, Ute Friedel, Francisca Oberhänsli, Barbara Willi, Karin Kull |
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| Přispěvatelé: | University of Zurich, Peterhans, Sophie |
| Rok vydání: | 2020 |
| Předmět: |
nontuberculous mycobacteria
10253 Department of Small Animals Tuberculosis 040301 veterinary sciences 3400 General Veterinary 10184 Institute of Veterinary Pathology Tuberculin vole bacillus 0403 veterinary science 03 medical and health sciences Mycobacterium microti Medicine interferon-gamma assay Pathogen 10082 Institute of Food Safety and Hygiene 030304 developmental biology Original Research 0303 health sciences gamma assay CATS lcsh:Veterinary medicine 630 Agriculture General Veterinary biology business.industry pyogranulomatous lymphadentitis interferon 04 agricultural and veterinary sciences biology.organism_classification medicine.disease Virology Mycobacterium tuberculosis complex 11404 Department of Clinical Diagnostics and Services 570 Life sciences lcsh:SF600-1100 Nontuberculous mycobacteria Veterinary Science Differential diagnosis business |
| Zdroj: | Frontiers in Veterinary Science, Vol 7 (2020) Frontiers in Veterinary Science |
| DOI: | 10.5167/uzh-195919 |
| Popis: | Public interest in animal tuberculosis is mainly focused on prevention and eradication of bovine tuberculosis in cattle and wildlife. In cattle, immunodiagnostic tests such as the tuberculin skin test or the interferon gamma (IFN-γ) assay have been established and are commercially available. Feline tuberculosis is rather unknown, and the available diagnostic tools are limited. However, infections with Mycobacterium tuberculosis complex members need to be considered an aetiological differential diagnosis in cats with granulomatous lymphadenopathy or skin nodules and, due to the zoonotic potential, a time-efficient and accurate diagnostic approach is required. The present study describes 11 independent cases of Mycobacterium microti infection in domestic cats in Switzerland. For three cases, clinical presentation, diagnostic imaging, bacteriological results, immunodiagnostic testing, and pathological features are reported. An adapted feline IFN-γ release assay was successfully applied in two cases and appears to be a promising tool for the ante mortem diagnosis of tuberculosis in cats. Direct contact with M. microti reservoir hosts was suspected to be the origin of infection in all three cases. However, there was no evidence of M. microti infection in 346 trapped wild mice from a presumptive endemic region. Therefore, the source and modalities of infection in cats in Switzerland remain to be further elucidated. |
| Databáze: | OpenAIRE |
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