Polymorphic Acetylator Phenotype and Systemic Lupus Erythematosus
| Autor: | Mauri J. Mattila, Kimmo K. Mustakallio, E. Johansson |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Observation period Provocation test Disease 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine medicine Humans Lupus Erythematosus Systemic Acetylator phenotype 030212 general & internal medicine skin and connective tissue diseases Aged Skin Tests Polymorphism Genetic business.industry Acetylation Sulfamethazine Complement System Proteins Middle Aged medicine.disease 3. Good health Phenotype Antibodies Antinuclear Immunology Female Syphilis business |
| Zdroj: | Acta Medica Scandinavica. 210:193-196 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1981.tb09799.x |
| Popis: | Out of 69 patients with spontaneous systemic lupus erythematosus (SLE), phenotyped for polymorphic acetylation with sulphadimidine, 52 (75%) were slow acetylators. In the subgroup of SLE patients with chronic biologically false positive seroreactions for syphilis the percentage of slow acetylators was even higher, 88%. In the majority of the slow acetylators the disease had started later and had followed a milder course than in rapid acetylators. Cutaneous reactions suspected to be drug-induced were seen in 19 (17 slow acetylators) during an observation period of 3–7 years. The reactions were mostly of exanthematous or urticarial type but also fixed type of eruption was seen. Provocation tests with the suspected drug were performed in 14 patients. In 5 cases it could be demonstrated that the eruption was caused by the drug. The predominance of slow acetylators among our patients with spontaneous SLE was the same as has been observed in drug-induced SLE. This suggests a similar genetic background. |
| Databáze: | OpenAIRE |
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