Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation

Autor:	Ching Chi Wang, Chiao Wen Chen, Henryk A. Witek, Kwok-Kong Tony Mong, Xin Ru Li
Rok vydání:	2020
Předmět:	chemistry.chemical_compound Polymethylhydrosiloxane chemistry Reducing agent Organic Chemistry Side reaction Organic chemistry Glycosyl Physical and Theoretical Chemistry Carbohydrate Protecting group Biochemistry Stoichiometry
Zdroj:	Organic & Biomolecular Chemistry. 18:3135-3141
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d0ob00252f
Popis:	In this study, we report a new reductive etherification procedure for protection of carbohydrate substrates and its application for one-pot preparation of glycosyl building blocks. The reported procedure features the use of polymethylhydrosiloxane (PMHS) as a sub-stoichiometric reducing agent, which prevents the transilylation side reaction and improves the efficiency of the reductive etherification method. Application of the PMHS reductive etherification procedure for one-pot protecting group manipulation are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20aba93976c7c73797bcb90b0e9d4f84 https://doi.org/10.1039/d0ob00252f Zobrazit plný text záznamu