SUSTAINED INFLUENCE OF INFECTIONS ON PROSTATE-SPECIFIC ANTIGEN CONCENTRATION: AN ANALYSIS OF CHANGES OVER 10 YEARS OF FOLLOW-UP
| Autor: | William G. Nelson, Lori J. Sokoll, Elizabeth A. Platz, Charlotte A. Gaydos, William B. Isaacs, Remington L. Nevin, Debra J. Elliott, Siobhan Sutcliffe, Angelo M. De Marzo, Ratna Pakpahan, Marvin E. Langston, Jonathan M. Zenilman |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Oncology
Male medicine.medical_specialty Mononucleosis Urology Gonorrhea 030232 urology & nephrology Infections Article 03 medical and health sciences Young Adult 0302 clinical medicine Text mining Antigen Internal medicine Medicine Humans Urethritis Aged Chlamydia business.industry Medical record Prostatic Neoplasms Chlamydia Infections Prostate-Specific Antigen medicine.disease Prostate-specific antigen Infectious disease (medical specialty) 030220 oncology & carcinogenesis business Follow-Up Studies |
| Popis: | BACKGROUND: To extend our previous observation of a short-term rise in prostate-specific antigen (PSA) concentration, a marker of prostate inflammation and cell damage, during and immediately following sexually transmitted and systemic infections, we examined the longer-term influence of these infections, both individually and cumulatively, on PSA over a mean of 10 years of follow-up in young active duty US servicemen. METHODS: We measured PSA in serum specimens collected in 1995–7 (baseline) and 2004–6 (follow-up) from 265 men diagnosed with chlamydia (CT), 72 with gonorrhea (GC), 37 with non-chlamydial, non-gonococcal urethritis (NCNGU), 58 with infectious mononucleosis (IM), 91 with other systemic or non-genitourinary infections such as varicella; and 125–258 men with no infectious disease diagnoses in their medical record during follow-up (controls). We examined the influence of these infections on PSA change between baseline and follow-up. RESULTS: The proportion of men with any increase in PSA (>0 ng/mL) over the 10-year average follow-up was significantly higher in men with histories of sexually transmitted infections (CT, GC, and NCNGU; 67.7% versus 60.8%, p=0.043), systemic infections (66.7% versus 54.4%, p=0.047), or any infections (all cases combined; 68.5% versus 54.4%, p=0.003) in their military medical record compared to controls. CONCLUSIONS: While PSA has been previously shown to rise during acute infection, these findings demonstrate that PSA remains elevated over a longer period. Additionally, the overall infection burden, rather than solely genitourinary-specific infection burden, contributed to these long-term changes, possibly implying a role for the cumulative burden of infections in prostate cancer risk. |
| Databáze: | OpenAIRE |
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